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98 Болезни сельскохозяйственных животных UDC 619:578.842.1:57.082.26 STUDYING SENSITIVITY OF PRIMARY AND CONTINUOUS CELL CULTURES TO ISOLATES OF CLASSICAL SWINE FEVER VIRUS, RECOVERED IN 2015 V.L. Gavrilova 1 , O.S. Puzankova 2 , F.S. Igolkin 3 , B.L. Manin 4 , T.V. Zhbanova 5 1 Researcher, Candidate of Science (Biology), FGBI «ARRIAH», Vladimir; e-mail: gavrilova_vl@arriah.ru 2 Leading Researcher, Candidate of Science (Veterinary Medicine), FGBI «ARRIAH», Vladimir; e-mail: puzankova@arriah.ru 3 Head of Laboratory, Candidate of Science (Veterinary Medicine), FGBI «ARRIAH», Vladimir; e-mail: igolkin_as@arriah.ru 4 Leading Researcher, Candidate of Science (Biology), FGBI «ARRIAH», Vladimir; e-mail: manin_bl@arriah.ru 5 Head of the Graduate School, Candidate of Science (Biology), FGBI «ARRIAH», Vladimir; e-mail: zhbanova@arriah.ru Summary The paper is devoted to studying sensitivity of primary and continu- ous cell cultures to classical swine fever virus. As a result of the work performed it was determined that CSFV accumulation in primary porcine cell cultures: bone marrow, leucocytes, spleen, lymph nodes, alveolar macrophages, does not considerably differ from the such in continuous cell lines РК-15, А 4 ×С 2 . Primary porcine testicles and kidneys as well as continuous cell cultures of African green monkey kidneys (CV-1) and rhesus monkey kidneys (MARC-145) demonstrated low sensitivity to field isolates of the classical swine fever virus isolated in Russia in 2015. Key words: classical swine fever isolate, cell culture, virus titer, cell culture infectious dose, direct immunofluorescence test. Электронная Научная СельскоХозяйственная Библиотека