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208 Биотехнология UDC 619:615.371-02:636.52/58 STABILITY OF ESSENTIAL QUALITY PARAMETERS OF ASSOCIATED INACTIVATED EMULSION VACCINES FOR POULTRY DURING STORAGE D.А. Gleyzer 1 , D.L. Dolgov 2 , S.V. Frolov 3 , N.V. Moroz 4 , V.Yu. Kulakov 5 , Ye.А. Konstantinova 6 1 Senior Researcher, Candidate of Science (Veterinary Medicine), FGBI «ARRIAH», Vladimir; e-mail: gleyzer@arriah.ru 2 Leading Researcher, Candidate of Science (Veterinary Medicine), FGBI «ARRIAH», Vladimir; e-mail: dolgov@arriah.ru 3 Leading Researcher, Candidate of Science (Veterinary Medicine), FGBI «ARRIAH», Vladimir; e-mail: frolov@arriah.ru 4 Head of Laboratory, Candidate of Science (Veterinary Medicine), FGBI «ARRIAH», Vladimir; e-mail: moroz@arriah.ru 5 Leading Researcher, Candidate of Science (Veterinary Medicine), FGBI «ARRIAH», Vladimir; e-mail: kulakov@arriah.ru 6 Junior Researcher, FGBI «ARRIAH», Vladimir; e-mail: konstantinova@arriah.ru Summary Compliance of essential quality parameters of two associated inac- tivated emulsion vaccines produced by the FGBI «ARRIAH» used in poultry production (vaccine against Newcastle disease, avian infectious bronchitis, egg drop syndrome-76 and vaccine against avian infectious bronchitis, egg drop syndrome-76, infectious bursal disease) were tested for compliance with specifications during 30 months of storage at speci- fied time intervals. Found that the viscosity and stability of emulsions of both vaccines did not change from the initial standard specifications. Vaccines did not demonstrate increase in reactogenicity. Mean activity of all antigens of the tested vaccines was within the specifications. But lower limit of the confidence interval of regression of IB virus antigen level reached critical value after 18 months of storage. Based on the obtained results the following conclusion was made: the tested veterinary preparations maintain essential quality parameters during at least 18 months of storage (р≤0,05), and this period can be considered as their shelf life. Key words: egg drop syndrome-76, avian infectious bronchitis, New- castle disease, infectious bursal disease. Электронная Научная СельскоХозяйственная Библиотека