NED373393NED

141 Общие вопросы RESULTS OF VALIDATION OF THE PROCESS OF VIROLOGICAL SAFETY OF C1-INHIBITOR WITH THE USE OF AUJESZKY’S DISEASE VIRUS V.I. Diev 1 , S.K. Starov 2 , A.V. Konstantinov 3 1 DVSc, Professor, FGBI «ARRIAH», Vladimir; E-mail: diev@arriah.ru 2 Deputy Director, senior research worker, PhD (Veterinary Medicine), FGBI «ARRIAH», Vladimir 3 Head of Department, PhD (Veterinary Medicine), FGBI «ARRIAH», Vladimir Summary The validation of C1-inhibitor virological safety after introduction of modified Aujeszky’s disease virus strain «BK» and PEG-6000 was conduct- ed. The possibility of using pseudorabies virus as a model for hepatitis B vi- rus was established. The rate of virus reduction was high and it came up to 5,385±0,134 lg TCID 50 сm 3 . Key words: validation, virological safety, virus reduction, C1-inhibitor, Aujeszky’s disease virus. Электронная Научная СельскоХозяйственная Библиотека