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Актуальные вопросы болезней птиц и других видов животных 195 7. Baxendale, W. The results of field trials conducted with an inactivated vaccine against the egg-drop syndrome 76 (EDS-76) / W. Baxendale, D. Lutticken, R. Hein, I. McPherson // Avian Pathol. – 1980. – Vol. 9. – P. 77-91. 8. Immune response to recombinant capsid proteins of adenovirus in humans: anti- fiber and anti-penton base antibodies have a synergistic effect on neutralizing activity / H. Gahery-Segard, F. Farace, D. Goderin [et al.] // J. Virol. – 1998. – Vol. 72, № 3. – P. 2388-2397. 9. Nazerian, K. Structural polypeptides of type II avian adenoviruses analyzed by monoclonal and polyclonal antibodies / K. Nazerian, L.F. Lee, W.S. Payne // Avian Dis. – 1991. – Vol. 35, № 3. – P. 572-578. 10. Protective immunity against avian influenza induced by a fowl pox virus recombinant / J. Taylor, R. Weinberg, Y. Kawaoka [et al.] // Vaccine. – 1988. – Vol. 6, № 6. – P. 504-508. 11. Recombinant egg drop syndrome subunit vaccine offers an alternative to virus propagation in duck eggs / B. Gutter, E. Fingerut, G. Gallili [et al.] // Avian Pathol. – 2008. – Vol. 37, № 1. – P. 33-37. Determination of Optimal Concentration of EDS-76 Virus Fiber Recombinant Protein in a Vaccine Formulation Ye.A. Avsitidiysky, S.V. Frolov, A.V. Scherbakov, V.V. Borisov Summary Experimental samples of recombinant vaccine against egg-drop syndrome-76 with various concentrations of the virus fiber protein in an inoculation volume were prepared and tested in chicks. It was shown that vaccines with the protein concentration of 50 to 200 µg induced high specific antibody titers against EDS-76 virus in inoculated birds that were similar to levels induced by a serial inactivated vaccine. As a result, we determined a minimal concentration of the recombinant protein in the inoculation volume of the vaccine necessary to induce protective antibody titers – 50 µg. Электронная Научная СельскоХозяйственная Библиотека